Cancer is not a random genetic mutation. Cancer results from a long term metabolic, hypoxia, mineral and hormonal stress leaving some cells with no option but to stop using their mitochondria efficiently for energy in order to survive. When the mitochondria are not used, they can be considered junk wasting space and may be become poorly maintained or dismantled. This leads to the cell becoming inflexible in its fuel efficiency and remaining cancerous and using glycolysis for energy rather than using the more efficient mitochondrial OXPHOS. This results in the cell excreting lactate rather than water and carbon dioxide. This in turn makes the extracellular environment acidic and hostile to the immune system while making the intracellular environment alkaline and high in deuterium and signalling to remain cancerous and perhaps support an intracellular parasite like a fungal pathogen.
Cancerous cells can be persuaded and fixed by normal neighbours to become normal and well behaved, possibly by exchanging fresh mitochondria, or sharing some melatonin, or sunshine, supporting mitochondrial OXPHOS with oxygen and red/near-infrared light which will only harm a cancer cell and never a normal cell. Methylene blue is not toxic to normal cells and much more effective than the chemo drug Carboplatin. You don't always have to kill cancer cells and you never need to kill normal cells!
Giogi Dinkov believes that the metabolism of polyunsaturated and peroxidised fatty acids causes inflamation and the inhibition of pyruvate dehydrogenase complex (PDC) thus preventing the pyruvate from being converted to acetyl-CoA as needed for the mitochondrial processing and forcing the cell to convert the pyruvate to lactate instead (and export the lactate from the cell). He thinks polyunsaturated fats are metabolic inhibitors to mitochondria. Hence Giorgi recommends that polyunsaturated fats (PUFA) are *minimised* (seed oils, omega 3,omega 6, EPA, DHA, nuts, fish oil) despite the government recommendations that these are essential. This is reasonable as the double carbon bonds in polyunsaturated fats have an increased tendency to become oxidised. He is also not keen on certain amino acids such as methionine and cystein as these are only required in minute amounts and excess can cause hormonal changes. He recommends taking glycine amino acid or gelatin (which contains glycine) to help balance the excess methionine and cystein that may be present in meat. He is happy to include carbohydrates and sugars (but not corn starch). He is happy with greek yoghurt and cheeses and meat from grassfed animals and fully saturated fats from meat or coconut. He tolerates mono-unsaturated fat such as olive oil in small amounts, say 1 tablespoon per meal max. He thinks plants and salads have anti-nutrients and are best cooked to neutralise these. If you want the sulforaphane you must chop and crush the vegetable raw and leave for 40 minutes for the sulforaphane to be formed before cooking (or add raw mustard powder after cooking). Some other people think that cells take time to switch between carb burning and fat burning (the Randle Cycle) and are affected by the level of the hormone insulin. Due to this time delay they suggest not mixing high carbs and high fat in the same day. They may be right since Giorgi *is* overweight.
Giorgi also thinks that cancer is affected by inflammation and hormones. The hormones to avoid are cortisol and estrogen. Cortisol is caused by stress which is why stress is associated with cancer, so relax and meditate. As some hormones like estrogen (bad) can be manufactured from testosterone using the aromatase enzyme it is also useful to use an aromatase inhibiter to keep estrogen low (anastrozole, letrozole, exemestane, aspirin, salicyclic acid ). There is evidence that pancreatic cancer in particular has upregulated expression of aromatase (a member of the cytochrome P450 family, also known as the estrogen synthetase or estrogen synthase which converts testosterone to estrogen) and that administration of aromatase inhibitors such as anastrozole can reduce the estrogen.
The hormones to encourage are testosterone, dihydrotestosterone (DHT), and thyroid. His experiments injecting testosterone into cancers have reversed the cancer, suggesting that the ratio of estrogen/testosterone may be important to reduce to much less that 1 part estrogen to 10 parts testosterone in the cancer tissue).
Giorgi also thinks that increasing the acidity inside the cancer cell will change its signalling and behaviour. Acidity can come from dissolved carbon dioxide which can be increased by rebreathing the same air (or same pure oxygen) from a bag until your brain feels panic which indicates that a high level of carbon dioxide in the blood has been reached. The use of pure oxygen in the bag will prevent the oxygen being significantly depleted at the same time. It would help to stand on a vibration plate or bounce on a trampoline at the same time to speed lymph flow to poorly irrigated tumors. Others simply think that oxygen itself has a positive effect regardless of carbon dioxide and are looking to down regulate HIF-1alpha (hypoxia inducible factor 1 alpha) which is promoting the cancer metabolism. So pure oxygen in the bag has an extra advantage, so best to add this. This has been tested with a 66 litre bag with pure oxygen as the initial content of the bag. The bag to mouth junction was suspended from the ceiling and contact with mouth requiring the patient holding it in place with no straps so that in the event of unconciousness the patient would fall and the normal room air breathing would automatically resume. The result was 17 minutes of breaths before panic (while no exercise at heart rate of 70 bpm were possible before panic at 75 bpm) and the blood oxygen saturation remained at 99% all of the time so absolutely no red blood cell oxygen deprivation, only carbon dioxide increases. It should be noted that the body will detect the increase of acidity in the blood and the increase of CO2 concentration and will compensate by buffering the change using carbonate ions stored or recycled by the kidneys. It should also be noted that the increase in CO2 concentration will reduce the grip on oxygen by the haemaglobin in the red blood cells and possibly release more oxygen into the fluid and possibly reduce its uptake from the lungs if there was low oxygen there. In the case of very high oxygen in the lungs > 50% this is not likely to be a problem but would be for someone breathing less than 20% oxygen.
Giorgi has also experimented with aspirin, salicylic acid, and derivatives (e.g. 2,6-Dihydroxybenzoic acid) to acidify the tumor cell cytoplasm with very positive results. It is unclear how these have anticancer effects. These compounds and their metabolites are antioxidant, reduce the mitocondrial inner membrane potential, can chelate iron and can act as aromatase inhibitors thus reducing estogen. They are also metabolised in the gut and liver to other compounds like various Dihydroxybenzoic acids as are many other plant flavanoids e.g. 2,5-Dihydroxybenzoic acids is also found in abundance in plants and vegetables such as grapes, citrus fruits, Hibiscus rosa-sinensis, sesame, avocados, batoko plum, kiwi fruits, apple, bitter melon and black berries.
He has seen that 5 grams of conventional aspirin can be tolerated by humans and has found bioavailable derivatives (2,6-Dihydroxybenzoic acid) that will work at 0.5 grams. 1 human commenter (Cassiopeia) cured a breast cancer including an aspirin dose of 15mg/kg/day or 1g/day for a 71 kg human. These should be mixed with some carbonates, vitamin C, glycine, MSM to improve cell wall penetration. E.g. Alka-Seltzer.
Nobody (not even the self proclaimed experts) seems to understand the Randle Cycle and its implications for diet, diet timing, blood glucose, triglycerides and insulin, so do your your own research from as many sources as possible.
Methylene Blue Metabolic Therapy Restrains In Vivo Ovarian Tumor Growth
Rethinking Cancer Through Cellular Energy & Metabolism with Georgi Dinkov
At 13:22 2,6-Dihydroxybenzoic acid is more acidic than salicylic acid (2-hydroxybenzoic acid)
The Randle Cycle - How Your Body Chooses Between Glucose and Fat with Dr. Ben Bikman