Cancer Research for Information Only
Only your personal doctor or oncologist is permitted to advise you on cancer treatment regardless of their knowledge of current research. Discuss it with him.
So when you have discussed this with your NHS oncologist and his NHS
nutritionist and they give you a poor prognosis and say eat whatever
you like and be happy, you may want to do some research yourself!
Watch this story of a patient who did their own research From Stage 4 Cancer to
Remission: The Power of Integrative Oncology. Dr. Paul Marik, the
IMA Chief Scientific Officer, on hearing this story commented the
traditional current approach for most cancers is a complete and
utter failure and based on a hypothesis which is wrong.
See later links to Dr Marik's 18 proven cancer treatments.
Also watch another stage 4 patient who eventually did their own research. How Rick Noffke Healed from Stage 4 Lung Cancer Using Metabolic Therapies. A well as conventional care, he added a metabolic approach to cancer and started a low glucose ketogenic diet with butyrate esters, vitamins and supplements and plant products, saying this always increases the effectiveness of conventional treatments and reduced negative side effects. He also said that he got zero support for this from the conventional world and was in fact humiliated and bullied and brutalized by a lot of conventional doctors. He added fasting and says Valter Longo has done fantastic research (See Valter Longo section later in this document). He says you have to do 20 things to succeed and not just 1 thing.
Why bother to read this? There are people who were diagnosed with stage 4 metastatic cancer who did their own research, found what works, implemented it and are stable and still alive 6 years later. E.G. Guy Tenenbaum Watch the interview, read the 3000 comments including comments from many other survivors.
It is illegal to to claim or advertise *any* benefit of a drug or substance that affects your body unless licensed by the MHRA and prescribed by your doctor for the licensed effect. The research explored here is not advice but just education. Almost all substances researched here will never be tested , licensed or prescribed for cancer purposes. Not even your UK doctor can prescribe them without losing his license. The law says you must die *only* with licensed drugs delivered by licensed doctors. Nothing can be licensed which is unprofitable.
If you delegate your care to your trained and approved oncologist, you will not benefit from the last 100 years of research that will increase your chances of survival by more than 8 times. Only you have the right to experiment on yourself. Nobody else can do this. You should document it and share it as a case report whether good or bad. Be the exception.
How can I criticize the completeness of your oncologist's knowledge? Because 100 years ago, genius's such as Otto Warburg, Sir Hans Krebs, and Albert Einstein, cooperated to discover the metabolism mechanisms of cells and the particular distortions of metabolism in cancer cells. They invented the Metabolic Theory of cancer. Unfortunately an alternative theory called the Somatic Mutation Theory of cancer also existed and was adopted by mainstream medicine and used to waste huge amounts of time and research funding with very little effect on most patient outcomes. This inefficient theory is the one your oncologist is trained in. The truth is that cancer cells have a different usual metabolism preference (they ferment glucose and glutamine) and a different environment (hypoxic and acidic) and a different objective (selfish survival) to normal cells and can be targeted (or reformed) without affecting healthy cells. Did your oncology team mention carbohydrates? Urine pH? Butyrate? While a chemotherapy agent may attack one feature of cancer cell (it wanting to divide), a natural compound such as melatonin can reform the cancer cell in 15 ways at once. Did your oncology team mention melatonin?, vitamin D3?, deuterium depleted water? stage 4 complete remission cases?
This page is available online at https://www.askchristurner.com/cancer.html and is best read online with a big screen so you can follow the hyperlinks to studies and videos.
It costs a lot of money to educate and reward your oncologist and his regulators. You can be sure that unpatented interventions such as diet, nutrients, sleep, fasting, red light, iodine, immune system regeneration, oxygen and exercise are never going to be promoted even if they make success 4-8 times more likely. See video How to fight cancer and autoimmune disease by increasing T cell creation and activation naturally! which has the crazy notion that your own immune system is important in defeating cancer and give some clues as to why you may have cancer issues as you get older and when to fast.
Your oncologist is not trained in non-pharmaceutical treatments and is unlikely to be competent enough to advise you on diet, supplements, exercise, and immune system activation (with all the science). You need to take that responsibility on yourself. For example, if your oncologist suggests a chemotherapy session while you are not in an exact part of your fasted state then he maybe inflicting needless damage on your healthy cells and/or your immune system and reducing the chemo effectiveness by 500%. (see professor Valter Longo's clinical trial results in chapters from his book "Fasting Cancer" or Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence). There is private unpublished research into nuances to combining fasting and chemotherapy only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
There is no proof that if your urine pH is less than 7.5 your cancer treatments may fail though studies have shown survival graphs showing you may die twice as fast. This can be fixed for 50 pence per day (so clearly not of interest to the captured medical establishment) and your oncologist has no idea! (URGENT UPDATE: Urine pH and Cancer)
Of course there are many difficult to understand alternative and adjuvant cancer protocols which have not been proved more effective than conventional protocols so yes your oncologist can only recommend the current standard approved therapies and you should take them. However, there is no proof that it is reasonable to add other therapies unless there is a scientific evidence that their addition is more likely to be detrimental rather than positive or neutral. If one person dies adding an alternative therapy is that worse than 10000 people dying with standard therapy alone? Well yes it is to the non-scientists and that will include the media, relatives of the dead, or organizations wanting a compliant population. I say that there is no published conclusive scientific proof (p < 0.05) that additional therapies mentioned in this document *will* result in worse outcomes.
Your specific cancer may have its own specialist web site such as www.pancreaticcancer.org.uk This is well worth reading, as cancer is an emotional subject and very tricky to to talk about.
So from pancreaticcancer.org.uk they explain the surgical options.
- Whipple's procedure. also called pancreaticoduodenectomy (PD), is an operation to remove the head of the pancreas. The operation also involves removing the first part of the small intestine, called the duodenum, the gallbladder and the bile duct. You will likely need to take digestive enzymes with every meal. The five-year survival rate after a Whipple procedure (pancreaticoduodenectomy) is generally around 20% to 25%.
What about chemotherapy?
Gemcitabine, 5-FU, leucovorin, irinotecan, oxaliplatin, Capecitabine, nab-paclitaxel and cocktails of these drugs (FOLFIRINOX) are used. Generally the more drugs you combine, the more effective they are but the more toxic they are to normal cells including your own immune system. More often than not they become ineffective and the cancer becomes resistant, or the patient is unable to tolerate them. But the principal of using many treatments in combination is sound especially if they could be non-toxic to healthy cells. You will read later that Dr Longo has evidence that chemotherapy works much better when timed to occur during a Fasting Mimicking Diet.
Pancreatic cancer has the lowest survival of all common cancers, with five-year survival less than 7% (when treated conventionally). A trial showed that when a particular alternative treatment (Gonzalez protocol) was tested it was 7 times worse than chemotherapy for survival Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer. So you should always consider combining treatments.
Why is this particular cancer so aggressive? Because of the nature of the tumor cells. They escape the treatments, they hide out, and then they come back. And they grow again and they affect the liver and then they kill people. There is fibrosis, thick scar tissue, that initiates and protects the tumor.
Why is the current standard of care giving such poor cure rates?
As an example of just how standard oncology has been deluded by the Somatic Mutation Theory and Hanahan and Weinberg's original six hallmarks of cancer, the oncologists use the fact that cancer cells eat many times more glucose than normal cells to image them in PET scans, yet do not advise limiting glucose or carbohydrate via the diet. There is no proof that the metabolic characteristics of cancer are ignored by the standard of care. Mark Lintern, in his book has added more hallmarks and has rearranged Weinburg's now 10 hallmarks in order of importance and placed "Abnormal Metabolic Pathways" in first position.
There is no proof that better approaches are to utilise the bodies own immune system to defeat the cancer and recognise that the body has signaling mechanisms that can protect healthy cells while unprotecting cancer cells and regenerating organs with new healthy cells and rehabilitating the cancer cells rather than just killing them directly. Other cancer theories (Metabolic Theory, Cell Suppression Theory, Stem Cell Theory) have greater explanatory power, greater safety, greater efficacy and can be implemented with diet, lifestyle, supplements and repurposed drugs and hence makes the patient empowered and relevant in the curing of the cancer. There is no proof that such a more comprehensive attack on cancer with these "alternative" adjuvant therapies (diet, exercise, hyperthermia, supplements, oxygen, repurposed drugs etc) result in a 4 fold improvement in stage 4 cancer survival. See chemothermia Some stage 4 human cancer patients have taken Turkey Tail supplements, despite there being no proof that they enhance your natural immune system and also attack the cancer and have observed cancer shrinkage *before* chemotherapy has started Does Turkey Tail Really Works In Fighting Cancer? WATCH THIS!! | Stage 4 Cancer. Sadly the 100% positive effects in mice cannot be tested in humans since the human trials are obliged to receive standard chemotherapy as well (There is no proof that this has negative effects on immune system).
Rhonda Patrick explains how How Magnesium Reduces Your Risk of Cancer.
Chris from chrisbeatcancer explains the lymphatic system here. Rebounding exercise for lymphatic drainage (Best Exercise for your Immune System) Exercise with Oxygen Therapy (EWOT) is also an important thing and goes well with the rebounder. It is estimated that capillaries lose to the interstitium around 8 L/day of fluid that becomes afferent lymph; after reabsorption at nodes (usually several nodes along a typical lymphatic vessel pathway), the total postnodal (efferent) flow rate is about 4 L/day. That sounds like a stagnant pond to me. Please use your rebounder to increase this many fold. And breathe pure oxygen while you do this. It is possible to build this yourself. Ask me for details. There is increasing evidence linking tumor hypoxia with poor cancer prognosis. You need type M1 macrophages to kill a cancer. Oxygen helps type M1 macrophages. Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept
There is no proof that it would be helpful to starve the cancer and stop the signals that make it want to grow or misbehave. See how immunotherapy is progressing with Thymosin Alpha-1. There are lots of similar immune stimulants, even the humble mistletoe. Dr. Mikolaj Raszek talks about New proposed 10 interventions for all solid cancers with no damage to your normal cells!. The youtube researcher "Pottinger's Human" is very keen on supporting your immune system to fight cancer with 6g Taurine among others and doing periodic fasting. See his recent deep dive on Taurine, the NAD+ boosting, immune boosting amino acid your diet IS missing.. He advises against high dose vitamin C due to oxalate kidney stone risk, but does suggest aspirin, methylene blue and red light therapy. See his cancer explanation video Why autophagy saves cells and insulin destroys them - and why this reverses in tumor cells There is no proof that eating a fasting mimicking diet with inulin, acetate and butyrate supplementation, reduces pancreatic cancer. Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models Something as simple as drinking deuterium depleted water has benefit. Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer
Not every doctor or researcher is suffering from CDD (curiosity deficit disorder) or are afraid of being sacked if they fail to follow official guidelines. Some doctors have 40 years of experience, no personal money problems, no boss telling them what they are allowed to do and can choose to spend a long time understanding the problems.
What have these free doctors and researchers found?
Dr.Tullio Simoncini
Many decades ago as a cancer surgeon he found that the standard of
care was curing almost nobody (0% cures) and that he had fewer
cancer recurrences after surgery if he irrigated the wound with
sodium bicarbonate buffer solution (90% cures) with no proof other
that his own personal experience. He was jailed, barred and exiled
for using a non-approved treatment and anyone allowing him to speak
also faces prosecution even today. Dr. Simoncini believed that
cancer was caused by a fungus hence was called a quack. It does not
matter whether his theory is true or not since his actual treatment
actions (without proof) still produced extraordinary results that
are still reproducible today. Yes, there are many quackwatch
articles against bicarbonates but actual research studies always
show huge benefit to patients (and no-benefit to the drug
companies). Nowadays we might say that the acidic tumor
extracellular microenvironment (TME) surrounding the tumor can cause
the attacking immune cells to struggle. There is no proof that a
more alkaline TME would be more helpful. Sodium bicarbonate
irrigation after surgery is still not approved or taught or tested
in humans. (It has been significantly tested in mice and tried in 1
human: We also performed a case study of a patient with
ovarian cancer malignant ascites resistant to previous lines of
chemotherapy who underwent intraperitoneal perfusions with a sodium
bicarbonate solution, resulting in a significant drop of CA-125
levels from 5600 U/mL to 2200 U/mL and disappearance of ascites,
indicating the potential effectiveness of the treatment.
Tumor
alkalization therapy
It was also verified in 13
pancreatic cancer patients with simple oral sodium bicarbonate. The
median Overall Survival (OS) of patients with an increased urine pH
(pH > 7.0) in the alkalization group (n = 13) was significantly
longer than that of the control group (n = 89) (25.1 vs. 10.8
months; p < 0.005). To decode the jargon, the p-value < 0.005
means that the effect was very real and the chance of this being a
fluke is less than 1 in 200. Clinical
review of alkalization therapy in cancer treatment
Another
report of patients with small-cell lung cancer (SCLC) tested patient
survival with 12 patients on sodium bicarbonate, fruit and
vegetables and intravenous vitamin C with the chemotherapy and 15
patients on just the chemotherapy. Improved
Chemotherapy Outcomes of Patients With Small-cell Lung Cancer
Treated With Combined Alkalization Therapy and Intravenous Vitamin
C
The results on the graph showed 7
patients on the treatment group still alive after 60 months while
everyone in the control group were dead by 30 months. To be fair, it
was not double blinded and randomised as they actually asked the
patients if they wanted this therapy and the control group answered
no thanks
so the effect could be the positive mental attitude
of the yes
sayers, or the fruit and veg, but I think it was
the alkaline urine ph of 7.3. Remember your NHS doctor has to assign
you to the control group!. Proof costs billions so still this is not
proof that if your urine pH is less than 7.5 your cancer treatments
will fail and you will die twice as fast. This can be fixed for 50
pence per day and your oncologist has no idea! Here is a discussion
from Casey Peavler about urine pH. URGENT
UPDATE: Urine pH and Cancer Here is a highlight study in liver
cancer Effects
of alkalization therapy on hepatocellular carcinoma: a
retrospective study
There is private unpublished research into nuances of urine alkalinazation only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Dr. Ralph Moss
Since 1974, has been
the world's #1 source for unbiased, independently researched, cancer
information. Also The
Moss Report Store has many free downloadable guides and links to
useful supplements and studies. For example he shows and gives
"evidence" of the improvements to cancer outcomes by adding some
plant extracts to standard therapies e.g.
The "Big Five" Phytochemicals Targeting Cancer Stem Cells:
Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
.
Another plant based product Fermented Wheat Germ Extract which normalizes mitochondrial energy production in cancer cells was tested in humans as an non-toxic adjuvant to a pharma treatment. Mean Overall survival: 66.2 months (FWGE group) versus 44.7 months (control group), p = 0.0298.
Most recently Dr Moss presented research on Extra Virgin Olive Oil that showed huge benefits to cancer mortality. The most pronounced benefit was observed for gastrointestinal cancers, with a 60% lower mortality risk for those consuming over 50 g/day (SHR 0.39; 95% CI 0.21-0.73). The benefits are delivered by the polyphenols in the oil that sting your throat when you swallow them so you must buy the darkest, most raw extra virgin oil. Dr. Limor Goren explains how extra virgin olive oil has these benefits mTOR, Polyphenols and Using Olive Oil to Fight Cancer with Dr. Limor Goren Dr. Moss also investigates a hundred other neglected substances and treatments unsponsored by the medical establishment and suppliers. Treatments that put the patient as a responsible, active, educated, and motivated participant in his own cure. Listen to his podcasts on You Tube. Also another provider has a You Tube channel Plant-Based Wellness which summarises many natural anticancer agents in a short 5 minute video each which always includes a relevant research paper finding. E.g. Moringa Leaf, Chaga Fungus, Pumpkin seeds, etc.
Professor Valter Longo
Professor Longo , after decades of research, has found that cancer cells and normal cells are *differently* regulated by the availability of sugars and amino acids (nutrition). He calls this Differential Stress Resistance (DSR) and Differential Stress Sensitization (DSS).
You can find full information of the trials in his book "Fasting Cancer"
He has found that these effects are duration sensitive and found that a Fasting Mimicking Diet (FMD) (low nutrition) pulse lasting for 5 days is safe and effective.
During such a pulse, the normal cells become more robust, while the cancer cells become more sensitive.
On day 3-5 of the pulse, other anticancer treatments including toxic chemotherapy can be applied effectively with reduced damage to normal cells and increased damage to cancer cells. The caveat is that the toxins from the chemotherapy must be substantially removed before ending the fast and refeeding, so consult your doctor for the duration of these toxins in the body. Be cautious of refeeding while there are still toxins (including those released by dead cancer cells) in your body. During the refeeding, in the absence of toxins, the organs re-grow normal cells to make the organ younger and better than before.
Professor Longo recommends a Fasting Mimicking Diet be applied for 5 days every 3 or 4 weeks.
His experiments and trials also illustrate the importance of combining therapies. In therapy, 1+1 often equals 10.
- The FMD alone, all die.
- The chemotherapy alone, all die.
- The FMD + chemotherapy, all cured.
He finds the fasting mimicking diet tested in 45 human clinical trials including 15 metastatic cancer trials including pancreatic cancer is very effective and at least doubles the survival rate when combined with standard of care. See him recently interviewed at Dr. Valter Longo: My Trials Show That Fasting Kills Cancer
Professor Longo also advocates exercise to further support the metabolic changes during the fast. He also approves of adding high dose oral vitamin C for better results (again encouraging the appropriate type of immune cells, however currently only KRAS positive tumors respond to IV vitamin C and there is the oxalate issue). Conversely many other people advocate high oxalate foods for cancer such as vitamin C and spinach
Personally Professor Longo advocates not going longer that 12 hours between meals and that you do not skip breakfast. (though when adding chemotherapy up to 16 hours between meals may be tried.)
His Fasting Mimicking Diet can be purchased as a kit from prolon.co.uk for £205 but is also customisable to you by consulting a team of dieticians.
You could make your own. It is plant based , focuses on a macronutrient ratio designed to not upset your body while turning on your bodies natural mechanisms of surviving periods of low calories efficiently, such as fat burning, autophagy and reducing growth signaling. It's a 5-day period with specific calorie intake on Day 1: 10% protein, 56% fat, 34% carbohydrates (1,100 calories) Days 2-5: 9% protein, 44% fat, 47% carbohydrates (800 calories per day). The 5 day length is optimal for best healing. Shorter will miss growth hormone, stem cell signalling and autophagy and longer may result in a persistent lowering of your metabolism and loss of muscle. Some independant youtubers have also created their own versions of the FMD for example Fasting Mimicking Diet DIY | Tips & Guidelines | Part 3. The above youtube video also has in the description a link to join the community and get your free printable fasting menu. Here is my menu copy as a pdf. Note that I tried this 5 day diet (mostly raw vegetables) and it was far too much food for me to eat so I personally recommend halving the quantities of all the items. I think Valter Longo also halved this in his clinical trials as when published they had less calories than his public fasting mimicking diet. Perhaps he was concerned by the lack of medical monitoring in the general public. For a normal diet the best anti-cancer vegetables are best eaten raw and are spinach, garlic, broccoli, red/purple cabbage, and carrots.
It should be low methionine and low cysteine as some cancers are dependent on these amino acids, so legumes are the preferred source of proteins, being naturally low in these amino acids.:- Extra virgin olive oil, apples, chick peas might be useful to get a balance in 1 meal but you need 15 different meals to keep a human happy!
There is no proof that reducing the non-essential amino acid proline also reduces the clonogenicity of tumor cells. If you are taking chemotherapy during the fast some other experts such as Professor Thomas Seyfreid may like you to reduce the carbohydrates further and increase the ketones but Valter thinks that many patients will find this too hard and may faint.
The Chronometer App will be able to give you detailed information of the macronutrient and amino acid profile of recipes that you create.
In between the 5 day Fasting Mimicking Diet sessions, you can eat normally or use his Longevity Diet listed in his book the "The Longevity Diet".
On refeeding, your body will stimulate stem cells to renew your immune system cells including naive T-cells and the thymus gland, and even your pancreas, kidney etc if these have suffered damage by cancer, toxins etc.
There is private unpublished research into nuances of fasting diets only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Professor Angus Dalgleish
Professor Dalgleish has been researching immunity and cancer for many decades.
He has pioneered a non-specific vaccine for cancer which operates by stimulating the immune system in a good way.
This vaccine is heat-killed Mycobacterium Vaccae bacteria injected intradermally.
Unfortunately it is not profitable to improve cancer outcomes with a natural bacteria found everywhere in soil, so trials for approval cannot be funded.
The heat-killed Mycobacterium Vaccae can however be bought online for $40 from mud-plus as an oral supplement to feel "better".
Professor Dalgleish also promotes Vitamin D3 as an essential complementary component for any cancer treatment (There is no license or proof of this effect on the MHRA web site, only that it reduces rickets).
He says that your own T-cells are useful for fighting cancer and that these are reduced if you have taken an MRNA vaccine booster. The vaccine license calls this VAED Vaccine associated enhanced disease, though they don't mention cancer. So there is no proof that you should not have boosters! He also says that the government agencies that regulate health care and even charities like Cancer Research UK have been corrupted by Big Pharma to actively discourage alternative cancer treatments.He has also discovered the beneficial effects of Low Dose Naltrexone (LDN) (4.5 mg/day) in association with cancer and the immune system.
Low Dose Naltrexone and α-Lipoic Acid.
A clinical case was described in which a 64-year-old patient with metastatic renal cell carcinoma (RCC) was treated with combined therapy of LDN and α-lipoic acid (ALA). The effectiveness of the therapy was confirmed by normal glucose uptake in the left lung, to which the cancer had previously metastasized. Moreover, the patient reported less shortness of breath, improved well-being allowing a return to work, and a return to normal weight. The authors of the study hypothesized that LDN along with ALA contribute to the reduction of tumor mass and transition of the cancer into a dormant state. Positive effects of LDN+ALA therapy were also observed in a patient with pancreatic cancer with liver metastases. After long-term polytherapy, the patient reported significant improvement in quality of life, and the disappearance of cancer-related symptoms, which enabled him to return to work. Similar effects were noted in three additional patients diagnosed with pancreatic adenocarcinoma with liver metastases, B-cell lymphoma, and prostate adenocarcinoma.
Low Dose Naltrexone and Vitamin D and Vitamin C.
The use of polytherapy with LDN and vitamin D brought positive effects for a 58-year-old patient suffering from tonsillar-cystic tongue cancer without metastases. The patient refused conventional chemotherapy, radiotherapy, and surgical treatment, so the treating physician prescribed him therapy with LDN at a dose of 4 mg and vitamin D at a dose of 10,000 IU daily. and vitamin C at a dose of 2000 mg/day. The patient experienced significant improvement after 3 months of therapy, and assessments of the size and degree of tumor development two years after the start of treatment showed that the sizes of the tumor lesions had reduced from 3 cm to 1.6 cm, and the radiologist noted progressive tumor regression.
Low dose naltrexone will need to be prescribed by your doctor and supplied by a compounding pharmacy like Dixons, Scotland.
Jeff T Bowles
Jeff has studied Vitamin D3 plus essential safety co-factors like K2, magnesium, boron, zinc, selenium, copper, vitamin A and toxicity mechanisms from calcium. If all dosed correctly it is effective as an immune system regulator and tissue remodeller. Not just for preventing rickets!. He also self-experimented with dosing and collected accounts of another 1000+ self-experimenters because the medical establishment has no interest in non-profitable treatments and uses unreasonable fear and doubt and misinformation to discourage them. Jeff has a very open mind and he writes his intelligent thinking down with little editing High-Dose Vitamin D3, Mitochondrial Bioenergetics, and the Metabolic Theory of Cancer: A Potential for Prevention and Reversal
There is private unpublished research into nuances of melatonin and vitamin D3 only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Professor Russell Reiter
Professor Reiter has studied melatonin for many decades and it's actions in the human body over all age groups. It's not just for sleep! There is no MHRA proof or licence for melatonin other than 5mg for sleep or jet lag. There is no proof or license but it may have anticancer effects especially combined with other things like vitamin D. E.g. Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review) Melatonin and vitamin D added to conventional chemotherapy seems much better for the patient outcomes. There is no proof or license that there are significant signaling effects that reduce cancer such as reducing HIF1-alfa and VEGF.
There is private unpublished research into nuances of melatonin and vitamin D only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Dr. Eugene Shippen
Dr. Eugene Shippen treats patients and is not afraid to use all research and available products to help his patients. For example he found research on Melatonin's ability to control breast cancer stem cells and formulated a topical application for slow night release as well as oral drops for fast acting short term effects. See him interviewed here Dr Eugene Shippen on cancer
He also found research on the link between cancer and vitamin D
blood levels. He found a linear relationship to cancer with 82%
lower rate of cancer for Vitamin D levels > 60 ng/ml compared to
< 20 ng/ml (P=0.006). In fact the graph looks as if nobody can
get cancer above 80 ng/ml. His protocol recommends 20,000 IU daily
D3 and 150 mcg K2, up to 50 mg melatonin, 6 mg iodine from kelp and
Fucoidan concentrates from Japan, and topical magnesium oil. He will
use Calcifidiol activated form of vitamin D to protect patient
instantly. Sometimes the official RDA recommended daily amount is
not proven to be optimal for health for you personally and with your
own research you may benefit from many times the RDA e.g. with
Iodine and Vitamin D. There is a paper Effects
of Molecular Iodine/Chemotherapy in the Immune Component of Breast
Cancer Tumoral Microenvironment where it was demonstrated that the
5mg/day molecular I2 iodine supplement plus chemotherapy generated
the best antitumor response (smaller tumor size and cancellation of
chemoresistance) and increased the disease-free survival from 63% to
92% in five years in patients who received the iodine supplement
(i.e 5 times more likely to survive!). Yes this is 40 times the RDA
but is proven. Dietary intake of iodine in Japan is estimated to
range from 5.3 - 13.8 mg/day. 124 million people are doing this
already!. The Association for the Advancement of Restorative
Medicine say It may be beneficial for cancer patients to take
approximately 100 mg of iodine/iodide along with Vitamin B2 and
Vitamin B3.
Strangely, conventional medicine seems uninterested in
something that may make you 5 times more likely to survive. It is
hard not to attribute this to the fact that iodine is unpatentable
and costs nothing.
He finds research that having many covid vaccine injections reduces your immunity and increases the cancer deaths.
Dr Casey Peavler
Dr Peavler has created many You Tube videos documenting his analysis of cancer mechanisms and how to affect them with drugs, plants, and lifestyle and environment. He has found many mechanisms and many ways to affect each mechanism so many many hundreds of possible interventions. Unsuprisingly, some natural interventions affect a dozen mechanisms each! Evolution is a wonderful thing and is quite happy to spend a billion years getting things optimal!
It is well worth viewing all Dr Peavlers videos even if you cannot understand the individual papers as he openly explores all the narrow research and makes holistic connections. E.g. For the benefits of green matcha tea see:- EGCG DESTROYS Warburg Metabolism & BLOCKS Glutamine. For the benefits of melatonin see:- Melatonin KILLS Cancer: REVERSES Warburg Effect & INHIBITS Glucose. For the benefits of Vitamin D see:- Vitamin D KILLS Cancer: BLOCKS Glutamine Uptake and Utilization. For the benefits of Ivermectin see:- Ivermectin ENHANCES Chemo/Immunotherapy AND Metabolic Therapy. Ivermectin DISRUPTS Pro-Growth Signaling Pathways & TARGETS Cancer Stem Cells For the importance of tumor extracellular microenvironment (TME) see:- URGENT UPDATE: Urine pH and Cancer. He also links to sources of anti-cancer supplements in the video description should you not find your own sources. For ways to prevent cachexia see:- Cancer Cachexia: The HIDDEN Cycles You MUST Break. Importantly some natural compounds such as Melatonin, Vitamin D, Curcumin, Quercetin (onions), Genistein, Sulforaphane, Luteolin, Fisitin, ECGC, Urolithin A, Apigenin, Catechin, Silybinin (milk thistle), Berberine, Oleanolic acid (extra virgin olive oil), Capsaicin (chilli), Betulinic acid, Ursolic acid (apple skin, oregano, rosemary and thyme), Alpha Hederin (Nigella sativa), Cinnamon, Rhodiola, Zinc, Ivermectin, Metformin, Methylsulfonylmethane (MSM) and Fenbendazole can inhibit Lactate Dehydrogenase A (LDHA) and defeat cancer today when combined with metabolic therapy (low glucose). See NATURAL Inhibitors of Lactate Dehydrogenase (LDHA)
Ilyes Baghli
Ilyes Baghli has created a Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol
His protocol correctly uses multiple treatments in combination, and is not restricted to profitable drugs. His treatment (for high grade cancers) can include:
- Vitamin C (IV 1.5g/kg/day)
- Vitamin D (serum level > 80ng/mL)
- Zinc (serum level 120ug/dL)
- Ivermectin (2mg/kg/day)
- Fenbendazole (1000mg 3 times per week)
- DON
- Diet (900 kcal/day)
- Water fasting
- Exercise
- Oxygen Therapy
- Vitamin K2
- Vitamin E
- Coq10
- Niacinamide
- Methylene Blue
- Artemisinin + 5-aminolevulinic-acid
- Riboflavin
- Melatonin
He should take some advice from Dr Longo about diet and fasting as there is a timing issue. He should take some advice from Ralph Moss and Dr Peavler as there are numerous other useful natural supplements (green tea, garlic, curcumin, rocket, nattokinase, thyme oil, extra virgin olive oil, fermented wheat germ, quercetin, capsaicin, black seed oil, mistletoe, apigenin, ginger, milk thistle, aspirin, mushrooms, oat bran, rapamycin, berberine ).
Comparative clinical studies should be performed for this protocol although each individual element has be shown to be non-toxic.
Jane McLelland
Jane was a cancer sufferer who suffered the medical standard of care and found that she had to do her own research to cure herself of terminal cancers, more than once. She has now written books on her story and the most likely useful theories of cancer (metabolic) and how to use those theories to plan a treatment individualised to the patient and wholly in the interests of the patient.
Dr. Gary Huber
Dr. Gary Huber interviews Paul, a stage 4 Pancreatic Cancer survivor. Prior to any conventional treatment, Gary advised Paul to use an integrative approach to treat the cancer. This integrative treatment was to enhance Immune System and to Detox. It used :-
- Metatrol PRO
- Immpower + Turkey Tail mushroom
- Vitamin C and D
- Crucera (Sulphoraphane)
- Peptide - Thymosin-a1
- Low Carb diet
- As much exercise as you can manage
- Positive thinking. You will get better!
This integrative treatment alone reduced his cancer CA-19-9 blood markers from 434 to 167 (62% drop!) and the tumor size had also reduced in just 2 weeks before the conventional chemotherapy had started. After the chemotherapy (still with the integrative treatment which had added Glutamine, Theanine, N-Acetyl-cysteine as a protection against the toxic chemo) and surgery he is now cancer free. The integrative approach clearly worked very well in isolation and outstandingly in combination with conventional chemo and surgery. Paul, a stage 4 Pancreatic Cancer survivor
Dr. Paul E. Marik
Part of the the FLCCC organisation, Paul has reviewed repurposed drugs etc. Cancer Care: Repurposed Drugs & Metabolic Interventions in Treating Cancer It is very hopeful. Take a look at a quick summary of 18 alternatives unknown by your oncologist!. Discuss if he has the balls to prescribe all 8 proven alternative drugs which require prescription!. Alternative Cancer Treatments: 18 Proven Interventions
Frank Suarez
Very much a supporter of the metabolic theory of cancer and the bodies immune system, Frank advises adjusting your parasympathetic or sympathetic nervous system state to best support your health, immune system and mitochondrial energy metabolism. Basically lower glucose, insulin, stress, adjust blood alkalinity with hydration, potassium, magnesium, iodine, bicarbonates and vegetable juices, exercise, breathe, take enzymes such as pancreatin and bromelain, sleep, avoid wheat and processed food (emulsifiers), measure your heart rate variability, blood pressure, blood glucose, urine pH. He has many videos in Spanish. Very similar is the Gonzales Protocol and many pancreatic cancer survivals of many decades are documented in english in Success Cases The Gonzalez Protocol.
Dr Guy Abraham MD
Dr Guy Abraham, now deceased (apparently he fell in 2013 and hit his
head) once said Medical Iodophobia is the unwarranted fear
of using and recommending inorganic, non-radioactive iodine/iodide
within the range known from the collective experience of three
generations of clinicians to be the the safest and most effective
amounts for treating symptoms and signs of iodine/iodide deficiency
(12.5-50mg/day).
He also said Medical iodophobia has reached
pandemic proportions. It is highly contagious and has wreaked havoc
on the practice of medicine and on the U.S. population.
Thyroxine
has been the most prescribed drug in the U.S. for several years.
So, the manufacturers of thyroxine benefited tremendously from this
deception.
Orthoiodo-supplementation should be part of a
complete nutritional program, emphasizing magnesium instead of
calcium.
Medical textbooks contain several vital pieces of
misinformation about the essential element Iodine, which may have
caused more human misery and death than both world wars combined.
The market value of levothyroxine (a synthetic form of thyroxine) was valued at US$3.8 billion in 2023. What would you do to Dr Guy Abraham if your 3.8 billion income was threatened?.
50 mg of iodine is 333 times the current RDA for iodine yet has been demonstrated to be safe for a few weeks. See the leading iodine literate doctor Dr David Brownstein defending the efficacy and safety of iodine and mentioning the pancreas several times. Iodine And Cancer: A Surprising Link | Is Iodine Good For You? There are other doctors such as William Davis who point out iodine can act like an antibiotic and that a high oral dose can affect the microbes in your upper gut. But both doctors think the official guidelines are useless and would probably agree that 6 mg is better than the RDA. You can always apply iodine on your skin if you are worried about your mouth and upper gut microbiome. It is known to improve function, kill cancer and cure scars and fibrous cysts in hormonal organs such as breasts, uterus, and other organs such as the pancreas. Actually, Iodine induces apoptosis in breast cancer cells at concentrations which are healthy for the body as a whole. These concentrations can be attained by ingesting 50 mg per day of iodine and iodide (e.g. modern Lugols) (tapering eventually to 12.5 mg/day maintenance dose). What percentage of cancer patients have adequate iodine? Just 2.5%. The other 97.5% are deficient. Coincidence? Urinary Iodine Concentrations in Cancer Patients. More information at Breast Cancer Choices. There are lots of cofactors that you need to take iodine safely such selenium, magnesium, Vitamin B2, B3, vitamin C and sea salt. See Iodine Supplementation Guide for details. Personally, I am concerned that oral iodine will influence my mouth, stomach and gut microbiome so I prefer to take the lugol's iodine drops as paint on the skin wherever I have an undesired blemish such as a melanoma, mole, angioma, or dark patch.
Linus Pauling and Dr. Sarah Myhill
Linus Pauling did a study on the survival of 100 terminal cancer patients given 10g/day of Vitamin C. We conclude that there is strong evidence that treatment of patients in Scotland with terminal (untreatable) cancer with about 10 g of ascorbate (ascorbic acid, vitamin C) per day increases the survival time by the factor of about 3 for most of them and by at least 20 for a few (about 10%). Larger amounts than 10 g/day might have a greater effect. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer* (vitamin C) Note there is currently no upper limit for vitamin C. Note that it is possible to make liposomal vitamin C (better absorbed) at home using an ultrasonic bath. See: How to make Liposomal Vitamin C at home to save tons of money on your family's health - Carrie Brown. Dr Sarah Myhill is the current advocate for vitamin C. During a fasting mimicking diet, you could try some vitamin C before each meal , buffered with some bicarbonates (2g of bicarbonates neutralises 4g of vitamin C) and certainly immediately rinse to remove the ascorbic acid from your teeth!. Pancreatic cancer is known to be KRAS positive and so vitamin C is effective. Sarah is also keen on sulphur compounds such as methyl-sulfonyl methane (MSM). MSM, an organic sulfur, support methylation, oxygenation and is a foundation for transporting other things across cell membranes and so enhances all other supplements such as vitamin C and supports excretion of poisons. See: MSM: The Mineral Essential for Health
Gábor Somlyai and Stephanie Seneff
Gábor Somlyai has been studying cancer for 33 years and found that deuterium depleted water (DDW) can affect 500 cancer related genes and cell division and inhibit all cancers when combined with other therapies. The anti-cancer properties are related to reactive oxygen species from mitochondria and cell division so best to avoid anti-oxidants, avoid heavy exercise (lactate) and avoid saunas but do get oxygen and do eat animal proteins to encourage cell division. So best continue to use DDW during re-feeding following a fast. Normal water has 150 parts per million of deuterium atoms and reducing this to say 80 parts per million has a good effect. Animal fat has 118 parts per million. It is best to drink little external water and make your water from animal fat. However DDW is available at 18 ppm and works well combined with your cancer therapy as well as preventing recurrance after treatment. It increases median survival 5 fold. It does cost £15 per litre, but you could dilute it with normal water (150) to get double volume of water at 80 ppm. See The Deuterium Experts: How Light, Water & Mitochondria Shape Cancer | Gábor Somlyai Stephanie Seneff has also discovered how deuterium operates and thinks that cancer may be a survival reaction to mitochondrial stress intended to benefit the body by generating lactate for other cells to eat while sequestering the nasty deuterium. Unfortunately deuterium acts as a growth hormone causing the cell to multiply. Reduce the deuterium and increase the oxygen and the cancer cell will become normal. Stephanie suggests that deuterium depleted water can be created in the gut. Just reduce your consumption of unneeded external water ( a horrible 150 ppm) and generate your own water from metabolism e.g. burning fats or hydrogen. Cancer, deuterium, and gut microbes: A novel perspective In another paper she suggest mechanisms by which deuterium may be excreted. Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water? Lutein and beta-carotene can both sequester deuterium. Has she explained the carrot juice diet for cancer? Bilirubin, forming the yellow of urine and dark colour of feces might also take some deuterium with it when excreted. She suggests that imidazole rings may be able to be exploited to trap deuterium permanently. Did she say "azole"? like fenbendazole? Might this be how fenbedazole cures cancer? Probiotic histamine‐producing bacteria can beneficially impact pathological conditions, including cancer. Lactate is a low‐deuterium nutrient, compared to glucose. So is yogurt or kefir good? The worlds oldest lady at 117 years ate yogurt 3 times per day! Oral administration of L‐histidine improved ... To facilitate deuterium excretion and prevent overaccumulation, we have also described here several classes of organic molecules, including carotenoids, PUFAs, and the amino acid histidine, all of which appear to play pivotal roles in capturing deuterons and attaching them to labile carbon atoms, thereby allowing for their excretion via the bowel and kidneys. Antibiotics are bad. We need those gut microbes.
Kim JH
Kim JH is a prolific researcher! He actually tried an oral cancer treatment on live mice for 3 months in 2014. Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis. Liver tumor development was greatly inhibited in the H-ras12V transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer.
The great thing is that he shows pictures of the mouse liver and tumors after the 3 months and reveals the daily dose of MSM that the mice were receiving!. Approximately 560000 cases (of worldwide human liver cancer) are diagnosed each year and 550000 deaths are due to liver cancer. But it seems no-one (officially) has bothered to try MSM in human cancer patients in the 10 years since Kim JH did his research in mice. However note that humans and guinea pigs cannot produce their own vitamin C whereas mice, rats and hens and most other animals can. So definitely worth adding vitamin C to human trials.
How might that trial be designed? The mice received methylsulfonylmethane (MSM, 100 μg/g or 100mg/kg) (treated group, n = 6) every day for 3 mo. To convert to an equivalent human dose divide by 12.3 = 8.13 mg/kg. So for me at 80 kg my daily dose would be 80*8.13 = 650 mg. This sounds very low (We need to check). Let us look at tests for toxicity in 1-day old broiler chickens. Sub-chronic (1,500 mg/kg BW daily for 21 D) concentrations did not cause any adverse effects on growth or clinical outcomes and appeared to be absorbed and distributed throughout the body. Say chick has average weight of 100 grams like a hamster so divide dose by 7.4 so human dose 202 mg/kg. Multiply by my mass 80kg my dose is 16216mg = 16 grams.
Another study on rats in 1988 ! Use of Polar Solvents in Chemoprevention of 1,2-Dimethylhydrazine-Induced Colon Cancer It is not clear what the dose was. The MSM was 1% in the drinking water?. Rats drink 30 ml per day so 0.3g MSM. If I drank 0.5 liter per day that would be 5 grams. Experiment lasted 9 months. 25 rats in each group. 5 rats in control group did not get tumor. 11 rats in MSM group did not get tumor. Not significant!. The control group had 10 grade-3 tumors. The MSM group had 3 grade-3 tumors.
Dr Janel allows her patients (with SIBO) to ramp up MSM supplementation to 30g/day for 8 weeks so it not toxic. An unofficial cancer protocol for humans combines MSM with liposomal vitamin C. After testing for allergies with tiny doses, this is slowly ramped up to 12g MSM and 1g liposomal vitamin C up to 5 times per day with the liposomal vitamin C given 1/2 hour after the MSM. So this could total 60g MSM and 5g liposomal vitamin C.
Can AI help me find information of what things could help treat my cancer?
Yes. You need to prompt the AI with a sufficiently detailed question
to get relevant answers. E.g. you will want to include the term in
vivo
which will show that you want live animal experiments since
you are a live animal and are likely to respond similarly. So any
example AI prompt would be:-
how does turkey tail extract reduce tumor size before chemotherapy has started?
why has turkey tail been included in standard guidelines in china and japan for 30 years but not in UK?
are there any pancreatic cancer experiments of milk thistle in vivo showing benefit?
are there any pancreatic cancer experiments of bicarbonate in vivo showing benefit?
are there any pancreatic cancer experiments of aspirin in vivo showing benefit?
for someone who already has metastatic pancreatic cancer does increasing vitamin D and vitamin k2 and magnesium affect mortality?
how does melatonin inhibit cancer metastasis
how do you explain exceptional responses in cancer patients
Do not trust the results! Always follow any references to check they are accurate and that AI has not invented or misinterpreted them, (or has been fooled by deliberate misinformation).
You may be a little suspicious of non-toxic non-approved treatments so let's look at how official cancer sites bust some myths unraveling some of the mysteries and misconceptions about cancer and cancer treatment (just the truths here, I can't possibly repeat the myths)
- Cancer is merely a blanket term for hundreds of diseases, the goal can’t be just one cure, but potentially dozens—even hundreds.
- There’s absolutely no evidence that doing a biopsy or removing the cancer will make it spread.
- No studies have shown that eating sugar will make your cancer worse or that, if you stop eating sugar, your cancer will shrink or disappear.
- Surgery is always needed, if possible, with these solid tumors.
- We have a lot of good things that we do to reduce or even eliminate a lot of these side effects.
- Only a small percentage of breast lumps turn out to be cancer.
- Although side-effects may result from chemotherapy, the actual infusion process or oral form of chemotherapy is not necessarily painful.
- Women who are diagnosed with cancer while pregnant may still have options available to them.
- Ninety-nine percent of the time the hair grows back whenever we finish or complete the course of chemotherapy.
- For the most part, in early stages— stage I and stage II—the chances of the cancer coming back is less likely. Even in later stages, there is hope that it won’t return.
- Most of the time, oncologists and cancer doctors do not feel bad if the patient wants to try a complementary or unusual approach to treat cancer.
- There is no therapeutic role for oxygen in cancer. Presenting higher than normal concentrations of oxygen to treat cancer has not been proven scientifically to kill the disease.
- There has been no link found between artificial sweeteners and cancer.
- There is no evidence that the use of cell phones, wireless headphones, or other similar devices is linked to cancer.
- Researchers have not found compelling evidence linking cancer to residential magnetic fields.
- In some cases, you may catch a virus that can lead to cancer, like the human papillomavirus (HPV), or encounter cancer-causing bacteria like Helicobacter pylori (H. pylori).
- There is no scientific basis for calling them superfoods, and there is no evidence to support the idea that they prevent cancer.
- There are no studies that conclusively point to stress itself as a cause of cancer.
- However, only five to ten percent of cancers are hereditary. A more significant percentage of cancers develop from mutations resulting from lifestyle choices, environmental factors, or aging.
- Cancer can affect anybody at any time regardless of your family history.
- Creating medicines that are safe as well as effective often means they are slow to get to market. It has nothing to do with theories such as government population control through disease or restriction of funding.
- Mankind has created a lot of things, both good and bad, but cancer isn’t one of them.
- Cancer is a complicated disease that is harder to study due to its constant mutation of healthy cells. In fact, the word cancer is used to describe over 100 related diseases which often have different properties.
- There is little evidence to suggest that a person’s cancer risk is increased by using personal care products, such as cosmetics, deodorants, and hair dyes.
- When it comes to cancer risk, it’s what you eat, not how you heat it up, that matters.
- There’s no good evidence to prove that our diet can change our whole body’s pH, or that a diet of a certain pH has any impact on cancer.
- It’s impossible to know for sure what causes each person’s cancer.
- Charities and government-funded scientists are free to investigate promising treatments without a profit motive.
- We also understand that we still have a long way to go until we have effective, kinder treatments for all types of cancer. It’s something we’re striving for every day.
- Scientists have proved that cancer begins due to faults (mutations) within our bodies’ own cells.
- Because scientists can easily distinguish between human and fungal cells, it’s clear that cancer isn’t a fungus.
- High doses of sodium bicarbonate are poisonous and can lead to very serious consequences. There are no published clinical trials testing it as a treatment for cancer, which means there’s no evidence to support using it.
- There is no good evidence that fasting reduces overall cancer risk.
- Calcium is needed for strong bones and teeth.
- There is not enough conclusive research that a plant-based diet will reduce the risk of cancer.
- There is no scientific evidence that lemon juice can prevent cancer.
- There is no convincing scientific evidence that links a person’s “attitude” to their risk of developing or dying from cancer.
- No herbal products have been shown to be effective for treating cancer.
- There’s no reliable evidence from studies of people that food and drinks stored in plastic cause cancer.
- Leftover pesticides on food does not cause cancer.
- There isn’t enough good-quality evidence to be certain that exposure to pesticides at high levels causes cancer.
- There is no strong evidence that being exposed to pesticides at low levels causes cancer.
- Around 2 in 100 cancer cases in the UK (2015) are linked to ionising radiation. This includes radon-related lung cancers, many of which could be prevented by not smoking.
- Even for scans that use higher doses of ionising radiation, the risk of cancer is still low and is outweighed by the importance of getting the right diagnosis and treatment.
- With the use of modern immunotherapy, up to 40% of patients with stage 4 melanoma are curable, and 50% of patients with stage 4 colon cancer metastatic to the liver can be cured with a combination of chemotherapy and surgery.
- There is no increase in breast cancer risk for women who received ovarian stimulation drugs compared with the general population.
- There is evidence to support that stress does not increase breast cancer risk.
- There is nothing that a woman can do to eliminate breast cancer risk.
- There is absolutely no evidence that mammograms cause breast cancer.
- We believe cannabis represents a risk factor,but we need more long-term studies.
- There are a few studies indicating that several dietary antioxidants, like carotenoids and vitamin C may protect against lung cancer, but the results overall are somewhat ambiguous.
- Cholesterol is an animal product, so items that contain saturated fat will not only increase cholesterol but increase specifically the ‘bad,’ or LDL, cholesterol, which then gets deposited in the arterial wall of our blood vessels.
- While some older cancer treatments may not be as kind as more modern therapies, they don’t make cancer worse.
- There is no link between vaccines and an increased risk of cancer. Cancer patients can’t receive vaccines when undergoing treatment, since their immune systems are usually weakened by these therapies and vaccines require someone to have a functioning immune system in order to work properly.
- The tumour microenvironment – which is the area of cells and tissues that directly surrounds a tumour – tends to be acidic. Each organ and tissue in your body has its own optimum pH range in which it functions best, and your body has incredibly tightly regulated systems to make sure the pH never goes outside of this range. You cannot change the pH of your body by eating alkaline foods. The first place anything you consume goes is your stomach, which is a nice big bath of pH 2 hydrochloric acid.
- Sharks get cancer at a rate much lower than humans, but they do still get the disease.
- There is no reliable evidence that it works as a cancer treatment – or as a treatment for anything else. It’s not available for sale in the UK or Europe, due to lack of evidence of its effectiveness.
- Suggesting that there’s some kind of conspiracy to make money by holding back a lifesaving cure for cancer insults the people who contribute every day to finding new ways to prevent, diagnose and treat the disease.
- Our cells have evolved repair kits to fix mutations and prevent cancer from developing but unfortunately, this doesn't always work.
- Another reason that pancreatic cancer is hard to treat is that when a tumour develops in the pancreas, it is often surrounded by thick scar tissue that makes treatment like chemotherapy less effective. Not only this, but this thick tissue prevents nutrients from entering the tumour – so the cells become especially strong to be able to survive in difficult conditions. This in turn makes the cells more resistant to chemotherapy drugs.
- There are no controlled, large-scale studies (studies with the most robust scientific evidence) that demonstrate an increased cancer risk following COVID-19 vaccination.
When healing turns into killing – the pathophysiology of pancreatic and hepatic fibrosis
Pawel E. Ferdek et al. J Physiol 600.11 (2022)These authors go into great detail about mechanisms and possible treatments of the fibrosis and cancer evolution in both the pancreas and liver which have much in common. I will highlight things that I would investigate changing with diet and lifestyle changes if I had these problems. Only your licensed doctor can give you advice so discuss it with him.
Fibrosis typically follows prolonged
inflammation that has failed to resolve, gradually resulting in
the replacement of cellular components with a stiff fibrotic scar,
which substantially impairs normal tissue functions.
a persistent irritant cause
viral hepatitis, cholangitis (inflammation of the bile duct
system), drug toxicity, chronic alcohol abuse and
non-alcoholic steatohepatitis (NASH)
(Fatty Liver caused by
excess carbohydrates or lack of essential saturated fat
C15:0 from grass fed butter
) pancreatic cancer
acinar cells, which secrete digestive
enzymes, and islets of Langerhans, which release hormones such as
insulin, glucagon or somatostatin.
Once the tissue integrity has been disrupted, immune
cells or platelets start releasing pro-inflammatory
cytokines and chemokines
myofibroblasts are usually removed
via apoptotic cell death
as vitamin A-storing, stellate-shaped cells,
Quiescent PSCs also store retinoids as lipid
droplets in the cytoplasm
Importantly, PSCs have been shown to regulate inflammation,
angiogenesis and cancer cell biology via secretion of cytokines
and growth factors
by releasing NO, the same cells have a reducing
effect on HSC proliferation
T helper type 2 cells (Th2) promote fibrosis by
producing interleukins IL-4, IL-5, IL-13, whereas natural
killer cells (NK) secrete interferon gamma (IFN-γ ) that induces
HSC apoptosis and inhibits the development of fibrosis. showed
that a vasodilator Fasudil effectively prevented
thioacetamide-induced liver fibrosis in a mouse model – this
inhibitor of the Rho-associated protein kinase (ROCK) not only activated
NK cells, but also inhibited proliferation of HSCs and induced
their apoptosis . It was observed that in patients with advanced
stages of fibrosis the activity of NK cells was inhibited
Bile
acids and ethanol metabolites, common inducers of AP,
exert direct damage on PACs and trigger local organ autodigestion
Other factors that could play a role in PSC activation
include oxidative stress generated during ethanol
metabolism , hypoxia and hyperglycaemia
In PSCs, by targeting a G protein-coupled oestrogen receptor
(GPER) with its agonist tamoxifen (a chemotherapeutic
agent used to treat breast cancer), YAP was deactivated, the
process of differentiation towards myofibroblasts was inhibited and
the capacity for remodelling of ECM in pancreatic cancer was
reduced
all-trans retinoic acid (ATRA), an active
metabolite of vitamin A, was shown to downregulate actomyosin
contractility, decrease generation of high traction forces and
desensitise PSCs to the mechanical cues from the ECM
Accumulating
evidence suggests that mechanisms under- lying the development of
fibrosis in various organs are controlled by Ca2+
signals.
Redox-active species are predominantly
generated as by-products of oxidative phosphorylation,
Redox-active
species are also produced by immune cells, for example, neutrophils
and macrophages, during inflammatory processes in the
tissue
For example, supplementation with vitamins or small
molecule antioxidants relieved severe abdominal pain in patients
with chronic pancreatitis
supplementation with a potent antioxidant, coenzyme
Q10 (CoQ10 ), caused a drop in hepatic fibrosis score. CoQ10 has
already been used successfully in numerous randomised clinical
trials
There is a growing consensus that changes in the extracellular
pH may promote certain diseases, including those with fibrotic
basis. Solid tumours of the pancreas are characterised by a
microenvironment that is not only highly fibrotic but also acidic
cancer cells employ mechanisms to extrude excess acids, at
the same time lowering the extracellular pH of the
tumour microenvironment
fuelling a vicious circle of micro-
environmental acidification
lower interstitial pH, which
was attributed to impaired blood flow
Non-alcoholic fatty liver disease (NAFLD) is a condition
characterised by improper intrahepatocyte storage of excess lipids,
mostly triglycerides.
vitamin B12 deficiency
However, changes
in the patient’s lifestyle, for example, modification of dietary
habits and regular physical activity, can help to
relief NASH symptoms
the extensive deposition of ECM proteins may physically
compress capillaries and limit oxygen diffusion through the
severely distorted architecture of the pancreatic parenchyma, which
leads to hypoxic conditions in the developing tumours.
type 2 diabetes mellitus , a metabolic disorder
characterised by impaired functions of β-cells and insulin
resistance,
silibinin (the main compound of silymarin
extracted from milk thistle)
In attempts to restore quiescence in PSCs , ATRA
or vitamin D receptor (VDR) ligands have been tested. As mentioned
before, ATRA was demonstrated to restore the quiescent phenotype in
PSCs in vitro owing to the downregulation of actomyosin
contractility through a retinoic acid receptor β
(RAR-β)-dependent mechanism (Chronopoulos et al., 2016), whereas calcipotriol,
a VDR ligand, substantially reduced fibrosis in both pancreatitis
and human tumour stroma