This page is available online at https://www.askchristurner.com/cancer.html and is best read online with a big screen so you can follow the hyperlinks to studies and videos.
It costs a lot of money to educate and reward your oncologist and his regulators. You can be sure that unpatented interventions such as diet, fasting, red light, iodine, immune system regeneration, oxygen and exercise are never going to be promoted even if they make success 4 times more likely. See video How to fight cancer and autoimmune disease by increasing T cell creation and activation naturally! which has the crazy notion that your own immune system is important in defeating cancer and give some clues as to why you may have cancer issues as you get older and when to fast.
Your oncologist is not trained in non-pharmaceutical treatments and is unlikely to be competent enough to advise you on diet, supplements, exercise, and immune system activation (with all the science). You need to take that responsibility on yourself. For example, if your oncologist suggests a chemotherapy session while you are not in an exact part of your fasted state then he maybe inflicting needless damage on your healthy cells and/or your immune system. (see professor Valter Longo's clinical trial results in chapters from his book "Fasting Cancer" or Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence). There is private unpublished research into nuances to combining fasting and chemotherapy only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
There is no proof that if your urine pH is less than 7.5 your cancer treatments may fail though studies have shown survival graphs showing you may die twice as fast. This can be fixed for 50 pence per day (so clearly not of interest to the captured medical establishment) and your oncologist has no idea! (URGENT UPDATE: Urine pH and Cancer)
Of course there are many difficult to understand alternative and adjuvant cancer protocols which have not been proved more effective than conventional protocols so yes your oncologist can only recommend the current standard approved therapies and you should take them. However, there is no proof that it is reasonable to add other therapies unless there is a scientific evidence that their addition is more likely to be detrimental rather than positive or neutral. If one person dies adding an alternative therapy is that worse than 10000 people dying with standard therapy alone? Well yes it is to the non-scientists and that will include the media, relatives of the dead, or organizations wanting a compliant population. I say that there is no published conclusive scientific proof (p < 0.05) that additional therapies mentioned in this document *will* result in worse outcomes.
Your specific cancer may have its own specialist web site such as www.pancreaticcancer.org.uk This is well worth reading, as cancer is an emotional subject and very tricky to to talk about.
So from pancreaticcancer.org.uk they explain the surgical options.
Gemcitabine, 5-FU, leucovorin, irinotecan, oxaliplatin, Capecitabine, nab-paclitaxel and cocktails of these drugs (FOLFIRINOX) are used. Generally the more drugs you combine, the more effective they are but the more toxic they are to normal cells including your own immune system. More often than not they become ineffective and the cancer becomes resistant, or the patient is unable to tolerate them. But the principal of using many treatments in combination is sound especially if they could be non-toxic to healthy cells. You will read later that Dr Longo has evidence that chemotherapy works much better when timed to occur during a Fasting Mimicking Diet.
Pancreatic cancer has the lowest survival of all common cancers, with five-year survival less than 7% (when treated conventionally). A trial showed that when a particular alternative treatment (Gonzalez protocol) was tested it was 7 times worse than chemotherapy for survival Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer. So you should always consider combining treatments.
Why is this particular cancer so aggressive? Because of the nature of the tumor cells. They escape the treatments, they hide out, and then they come back. And they grow again and they affect the liver and then they kill people. There is fibrosis, thick scar tissue, that initiates and protects the tumor.
There is no proof the current standard of care just cuts, burns or poisons cancer and normal cells alike, rarely cures, and often spreads the cancer with surgery or biopsy. There is no proof that the standard of care only intends delaying the cancer progression for a few months. There is no proof that the current standard of care has a narrow view of the nature of cancer (Somatic Mutation Theory) and a narrow view of solutions that must be very profitable for some organization.
As an example of just how standard oncology has been deluded by the Somatic Mutation Theory and Hanahan and Weinberg's original six hallmarks of cancer, the oncologists use the fact that cancer cells eat many times more glucose than normal cells to image them in PET scans, yet do not advise limiting glucose or carbohydrate via the diet. There is no proof that the metabolic characteristics of cancer are ignored by the standard of care. Mark Lintern, in his book has added more hallmarks and has rearranged Weinburg's now 10 hallmarks in order of importance and placed "Abnormal Metabolic Pathways" in first position.
There is no proof that better approaches are to utilise the bodies own immune system to defeat the cancer and recognise that the body has signaling mechanisms that can protect healthy cells while unprotecting cancer cells and regenerating organs with new healthy cells and rehabilitating the cancer cells rather than just killing them directly. Other cancer theories (Metabolic Theory, Cell Suppression Theory, Stem Cell Theory) have greater explanatory power, greater safety, greater efficacy and can be implemented with diet, lifestyle, supplements and repurposed drugs and hence makes the patient empowered and relevant in the curing of the cancer. There is no proof that such a more comprehensive attack on cancer with these "alternative" adjuvant therapies (diet, exercise, hyperthermia, supplements, oxygen, repurposed drugs etc) result in a 4 fold improvement in stage 4 cancer survival. See chemothermia Some stage 4 human cancer patients have taken Turkey Tail supplements, despite there being no proof that they enhance your natural immune system and also attack the cancer and have observed cancer shrinkage *before* chemotherapy has started Does Turkey Tail Really Works In Fighting Cancer? WATCH THIS!! | Stage 4 Cancer. Sadly the 100% positive effects in mice cannot be tested in humans since the human trials are obliged to receive standard chemotherapy as well (There is no proof that this has negative effects on immune system).
Rhonda Patrick explains how How Magnesium Reduces Your Risk of Cancer.
What could help the immune system get better at eating the cancer? There is no proof that T-helper cells type 1 (Th1) are generally better than Th2 at assisting other immune cells such as T and Natural Killer (NK) cells to target the cancer and give those immune cells the energy to work at full potential close to the cancer. There is no proof that it would be helpful to starve the cancer and stop the signals that make it want to grow or misbehave. See how immunotherapy is progressing with Thymosin Alpha-1. There are lots of similar immune stimulants, even the humble mistletoe. Dr. Mikolaj Raszek talks about New proposed 10 interventions for all solid cancers with no damage to your normal cells!. The youtube researcher "Pottinger's Human" is very keen on supporting your immune system to fight cancer with 6g Taurine among others and doing periodic fasting. See his recent deep dive on Taurine, the NAD+ boosting, immune boosting amino acid your diet IS missing.. He advises against high dose vitamin C due to oxalate kidney stone risk, but does suggest aspirin, methylene blue and red light therapy. See his cancer explanation video Why autophagy saves cells and insulin destroys them - and why this reverses in tumor cells
Not every doctor or researcher is suffering from CDD (curiosity deficit disorder) or are afraid of being sacked if they fail to follow official guidelines. Some doctors have 40 years of experience, no personal money problems, no boss telling them what they are allowed to do and can choose to spend a long time understanding the problems.
What have these free doctors and researchers found?
Many decades ago as a cancer surgeon he found that the standard of
care was curing almost nobody (0% cures) and that he had fewer
cancer recurrences after surgery if he irrigated the wound with
sodium bicarbonate buffer solution (90% cures) with no proof other
that his own personal experience. He was jailed, barred and exiled
for using a non-approved treatment and anyone allowing him to speak
also faces prosecution even today. Dr. Simoncini believed that
cancer was caused by a fungus hence was called a quack. It does not
matter whether his theory is true or not since his actual treatment
actions (without proof) still produced extraordinary results that
are still reproducible today. Nowadays we might say that the acidic
tumor extracellular microenvironment (TME) surrounding the tumor can
cause the attacking immune cells to struggle. There is no proof that
a more alkaline TME would be more helpful. Sodium bicarbonate
irrigation after surgery is still not approved or taught or tested
in humans. (It has been significantly tested in mice and tried in 1
human: We also performed a case study of a patient with
ovarian cancer malignant ascites resistant to previous lines of
chemotherapy who underwent intraperitoneal perfusions with a sodium
bicarbonate solution, resulting in a significant drop of CA-125
levels from 5600 U/mL to 2200 U/mL and disappearance of ascites,
indicating the potential effectiveness of the treatment.
Tumor
alkalization therapy
It was also verified in 13
pancreatic cancer patients with simple oral sodium bicarbonate. The
median Overall Survival (OS) of patients with an increased urine pH
(pH > 7.0) in the alkalization group (n = 13) was significantly
longer than that of the control group (n = 89) (25.1 vs. 10.8
months; p < 0.005). To decode the jargon, the p-value < 0.005
means that the effect was very real and the chance of this being a
fluke is less than 1 in 200. Clinical
review of alkalization therapy in cancer treatment
Another
report of patients with small-cell lung cancer (SCLC) tested patient
survival with 12 patients on sodium bicarbonate, fruit and
vegetables and intravenous vitamin C with the chemotherapy and 15
patients on just the chemotherapy. Improved
Chemotherapy Outcomes of Patients With Small-cell Lung Cancer
Treated With Combined Alkalization Therapy and Intravenous Vitamin
C
The results on the graph showed 7
patients on the treatment group still alive after 60 months while
everyone in the control group were dead by 30 months. To be fair, it
was not double blinded and randomised as they actually asked the
patients if they wanted this therapy and the control group answered
no thanks
so the effect could be the positive mental attitude
of the yes
sayers, or the fruit and veg, but I think it was
the alkaline urine ph of 7.3. Remember your NHS doctor has to assign
you to the control group!. Proof costs billions so still this is not
proof that if your urine pH is less than 7.5 your cancer treatments
will fail and you will die twice as fast. This can be fixed for 50
pence per day and your oncologist has no idea! Here is a discussion
from Casey Peavler about urine pH. URGENT
UPDATE: Urine pH and Cancer Here is a highlight study in liver
cancer Effects
of alkalization therapy on hepatocellular carcinoma: a
retrospective study
There is private unpublished research into nuances of urine alkalinazation only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Since 1974, has been
the world's #1 source for unbiased, independently researched, cancer
information. Also The
Moss Report Store has many free downloadable guides and links to
useful supplements and studies. For example he shows and gives
"evidence" of the improvements to cancer outcomes by adding some
plant extracts to standard therapies e.g.
The "Big Five" Phytochemicals Targeting Cancer Stem Cells:
Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
.
Another plant based product Fermented Wheat Germ Extract which normalizes mitochondrial energy production in cancer cells was tested in humans as an non-toxic adjuvant to a pharma treatment. Mean Overall survival: 66.2 months (FWGE group) versus 44.7 months (control group), p = 0.0298.
Most recently Dr Moss presented research on Extra Virgin Olive Oil that showed huge benefits to cancer mortality. The most pronounced benefit was observed for gastrointestinal cancers, with a 60% lower mortality risk for those consuming over 50 g/day (SHR 0.39; 95% CI 0.21-0.73). The benefits are delivered by the polyphenols in the oil that sting your throat when you swallow them so you must buy the darkest, most raw extra virgin oil. Dr. Limor Goren explains how extra virgin olive oil has these benefits mTOR, Polyphenols and Using Olive Oil to Fight Cancer with Dr. Limor Goren Dr. Moss also investigates a hundred other neglected substances and treatments unsponsored by the medical establishment and suppliers. Treatments that put the patient as a responsible, active, educated, and motivated participant in his own cure. Listen to his podcasts on You Tube. Also another provider has a You Tube channel Plant-Based Wellness which summarises many natural anticancer agents in a short 5 minute video each which always includes a relevant research paper finding. E.g. Moringa Leaf, Chaga Fungus, Pumpkin seeds, etc.
Professor Longo , after decades of research, has found that cancer cells and normal cells are *differently* regulated by the availability of sugars and amino acids (nutrition). He calls this Differential Stress Resistance (DSR) and Differential Stress Sensitization (DSS).
You can find full information of the trials in his book "Fasting Cancer"
He has found that these effects are duration sensitive and found that a Fasting Mimicking Diet (FMD) (low nutrition) pulse lasting for 5 days is safe and effective.
During such a pulse, the normal cells become more robust, while the cancer cells become more sensitive.
There is private unpublished research into nuances of timing of fasting only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Professor Longo recommends a Fasting Mimicking Diet be applied for 5 days every 3 or 4 weeks.
His experiments and trials also illustrate the importance of combining therapies. In therapy, 1+1 often equals 10.
Professor Longo also advocates exercise to further support the metabolic changes during the fast. He also approves of adding high dose oral vitamin C for better results (again encouraging the appropriate type of immune cells. There is private unpublished research into nuances of vitamin C only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Personally Professor Longo advocates not going longer that 12 hours between meals and that you do not skip breakfast.
His Fasting Mimicking Diet can be purchased as a kit from prolon.co.uk for £205 but is also customisable to you by consulting a team of dieticians.
You could make your own. It is plant based , focuses on a macronutrient ratio of approximately 10% protein, 45% fat, and 45% carbohydrates. It's a 5-day period with specific calorie intake on Day 1 (1,100 calories) and Days 2-5 (725 calories).
There is private unpublished research into nuances of fasting diets only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
In between the 5 day Fasting Mimicking Diet sessions, you can eat normally or use his Longevity Diet listed in his book the "The Longevity Diet".
Professor Dalgleish has been researching immunity and cancer for many decades.
He has pioneered a non-specific vaccine for cancer which operates by stimulating the immune system in a good way.
This vaccine is heat-killed Mycobacterium Vaccae bacteria injected intradermally.
Unfortunately it is not profitable to improve cancer outcomes with a natural bacteria found everywhere in soil, so trials for approval cannot be funded.
The heat-killed Mycobacterium Vaccae can however be bought online for $40 from mud-plus as an oral supplement to feel "better".
Professor Dalgleish also promotes Vitamin D3 as an essential complementary component for any cancer treatment (There is no license or proof of this effect on the MHRA web site, only that it reduces rickets).
He says that your own T-cells are useful for fighting cancer and that these are reduced if you have taken an MRNA vaccine booster. The vaccine license calls this VAED Vaccine associated enhanced disease, though they don't mention cancer. So there is no proof that you should not have boosters! He also says that the government agencies that regulate health care and even charities like Cancer Research UK have been corrupted by Big Pharma to actively discourage alternative cancer treatments.He has also discovered the beneficial effects of Low Dose Naltrexone (LDN) (4.5 mg/day) in association with cancer and the immune system.
Low Dose Naltrexone and α-Lipoic Acid.
A clinical case was described in which a 64-year-old patient with metastatic renal cell carcinoma (RCC) was treated with combined therapy of LDN and α-lipoic acid (ALA). The effectiveness of the therapy was confirmed by normal glucose uptake in the left lung, to which the cancer had previously metastasized. Moreover, the patient reported less shortness of breath, improved well-being allowing a return to work, and a return to normal weight. The authors of the study hypothesized that LDN along with ALA contribute to the reduction of tumor mass and transition of the cancer into a dormant state. Positive effects of LDN+ALA therapy were also observed in a patient with pancreatic cancer with liver metastases. After long-term polytherapy, the patient reported significant improvement in quality of life, and the disappearance of cancer-related symptoms, which enabled him to return to work. Similar effects were noted in three additional patients diagnosed with pancreatic adenocarcinoma with liver metastases, B-cell lymphoma, and prostate adenocarcinoma.
Low Dose Naltrexone and Vitamin D and Vitamin C.
The use of polytherapy with LDN and vitamin D brought positive effects for a 58-year-old patient suffering from tonsillar-cystic tongue cancer without metastases. The patient refused conventional chemotherapy, radiotherapy, and surgical treatment, so the treating physician prescribed him therapy with LDN at a dose of 4 mg and vitamin D at a dose of 10,000 IU daily. and vitamin C at a dose of 2000 mg/day. The patient experienced significant improvement after 3 months of therapy, and assessments of the size and degree of tumor development two years after the start of treatment showed that the sizes of the tumor lesions had reduced from 3 cm to 1.6 cm, and the radiologist noted progressive tumor regression.
Low dose naltrexone will need to be prescribed by your doctor and supplied by a compounding pharmacy like Dixons, Scotland.
Professor Reiter has studied melatonin for many decades and it's actions in the human body over all age groups. It's not just for sleep! There is no MHRA proof or licence for melatonin other than 5mg for sleep or jet lag. There is no proof or license but it may have anticancer effects especially combined with other things like vitamin D. E.g. Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review) Melatonin and vitamin D added to conventional chemotherapy seems much better for the patient outcomes. There is no proof or license that there are significant signaling effects that reduce cancer such as reducing HIF1-alfa and VEGF.
There is private unpublished research into nuances of melatonin and vitamin D only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Dr. Eugene Shippen treats patients and is not afraid to use all research and available products to help his patients. For example he found research on Melatonin's ability to control breast cancer stem cells and formulated a topical application for slow night release as well as oral drops for fast acting short term effects. See him interviewed here Dr Eugene Shippen on cancer
He also found research on the link between cancer and vitamin D
blood levels. He found a linear relationship to cancer with 82%
lower rate of cancer for Vitamin D levels > 60 ng/ml compared to
< 20 ng/ml (P=0.006). In fact the graph looks as if nobody can
get cancer above 80 ng/ml. His protocol recommends 20,000 IU daily
D3 and 150 mcg K2, up to 50 mg melatonin, 6 mg iodine from kelp and
Fucoidan concentrates from Japan, and topical magnesium oil. He will
use Calcifidiol activated form of vitamin D to protect patient
instantly. Sometimes the official RDA recommended daily amount is
not proven to be optimal for health for you personally and with your
own research you may benefit from many times the RDA e.g. with
Iodine and Vitamin D. There is a paper Effects
of Molecular Iodine/Chemotherapy in the Immune Component of Breast
Cancer Tumoral Microenvironment where it was demonstrated that the
5mg/day molecular I2 iodine supplement plus chemotherapy generated
the best antitumor response (smaller tumor size and cancellation of
chemoresistance) and increased the disease-free survival from 63% to
92% in five years in patients who received the iodine supplement
(i.e 5 times more likely to survive!). Yes this is 40 times the RDA
but is proven. Dietary intake of iodine in Japan is estimated to
range from 5.3 - 13.8 mg/day. 124 million people are doing this
already!. The Association for the Advancement of Restorative
Medicine say It may be beneficial for cancer patients to take
approximately 100 mg of iodine/iodide along with Vitamin B2 and
Vitamin B3.
Strangely, conventional medicine seems uninterested in
something that may make you 5 times more likely to survive. It is
hard not to attribute this to the fact that iodine is unpatentable
and costs nothing.
He finds research that having many covid vaccine injections reduces your immunity and increases the cancer deaths.
Dr Peavler has created many You Tube videos documenting his analysis of cancer mechanisms and how to affect them with drugs, plants, and lifestyle and environment. He has found many mechanisms and many ways to affect each mechanism so many many hundreds of possible interventions. Unsuprisingly, some natural interventions affect a dozen mechanisms each! Evolution is a wonderful thing and is quite happy to spend a billion years getting things optimal!
It is well worth viewing all Dr Peavlers videos even if you cannot understand the individual papers as he openly explores all the narrow research and makes holistic connections. E.g. For the benefits of green matcha tea see:- EGCG DESTROYS Warburg Metabolism & BLOCKS Glutamine. For the benefits of melatonin see:- Melatonin KILLS Cancer: REVERSES Warburg Effect & INHIBITS Glucose. For the benefits of Vitamin D see:- Vitamin D KILLS Cancer: BLOCKS Glutamine Uptake and Utilization. For the benefits of Ivermectin see:- Ivermectin ENHANCES Chemo/Immunotherapy AND Metabolic Therapy. For the importance of tumor extracellular microenvironment (TME) see:- URGENT UPDATE: Urine pH and Cancer. He also links to sources of anti-cancer supplements in the video description should you not find your own sources.
Ilyes Baghli has created a Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol
His protocol correctly uses multiple treatments in combination, and is not restricted to profitable drugs. His treatment (for high grade cancers) can include:
He should take some advice from Dr Longo about diet and fasting as there is a timing issue. He should take some advice from Ralph Moss and Dr Peavler as there are numerous other useful natural supplements (green tea, garlic, curcumin, rocket, nattokinase, thyme oil, extra virgin olive oil, fermented wheat germ, quercetin, capsaicin, black seed oil, mistletoe, apigenin, ginger, milk thistle, aspirin, mushrooms, oat bran, rapamycin, berberine ).
Comparative clinical studies should be performed for this protocol although each individual element has be shown to be non-toxic.
Jane was a cancer sufferer who suffered the medical standard of care and found that she had to do her own research to cure herself of terminal cancers, more than once. She has now written books on her story and the most likely useful theories of cancer (metabolic) and how to use those theories to plan a treatment individualised to the patient and wholly in the interests of the patient.
Dr. Gary Huber interviews Paul, a stage 4 Pancreatic Cancer survivor. Prior to any conventional treatment, Gary advised Paul to use an integrative approach to treat the cancer. This integrative treatment was to enhance Immune System and to Detox. It used :-
This integrative treatment alone reduced his cancer CA-19-9 blood markers from 434 to 167 (62% drop!) and the tumor size had also reduced in just 2 weeks before the conventional chemotherapy had started. After the chemotherapy (still with the integrative treatment which had added Glutamine, Theanine, N-Acetyl-cysteine as a protection against the toxic chemo) and surgery he is now cancer free. The integrative approach clearly worked very well in isolation and outstandingly in combination with conventional chemo and surgery. Paul, a stage 4 Pancreatic Cancer survivor
Part of the the FLCCC organisation, Paul has reviewed repurposed drugs etc. Cancer Care: Repurposed Drugs & Metabolic Interventions in Treating Cancer It is very hopeful. Take a look at a quick summary of 18 alternatives unknown by your oncologist!. Discuss if he has the balls to prescribe all 8 proven alternative drugs which require prescription!. Alternative Cancer Treatments: 18 Proven Interventions
Very much a supporter of the metabolic theory of cancer and the bodies immune system, Frank advises adjusting your parasympathetic or sympathetic nervous system state to best support your health, immune system and mitochondrial energy metabolism. Basically lower glucose, insulin, stress, adjust blood alkalinity with hydration, potassium, magnesium, iodine, bicarbonates and vegetable juices, exercise, breathe, take enzymes such as pancreatin and bromelain, sleep, avoid wheat and processed food (emulsifiers), measure your heart rate variability, blood pressure, blood glucose, urine pH. He has many videos in Spanish. Very similar is the Gonzales Protocol and many pancreatic cancer survivals of many decades are documented in english in Success Cases The Gonzalez Protocol.
Yes. You need to prompt the AI with a sufficiently detailed question
to get relevant answers. E.g. you will want to include the term in
vivo
which will show that you want live animal experiments since
you are a live animal and are likely to respond similarly. So any
example AI prompt would be:-
how does turkey tail extract reduce tumor size before chemotherapy has started?
why has turkey tail been included in standard guidelines in china and japan for 30 years but not in UK?
are there any pancreatic cancer experiments of milk thistle in vivo showing benefit?
are there any pancreatic cancer experiments of bicarbonate in vivo showing benefit?
are there any pancreatic cancer experiments of aspirin in vivo showing benefit?
for someone who already has metastatic pancreatic cancer does increasing vitamin D and vitamin k2 and magnesium affect mortality?
how does melatonin inhibit cancer metastasis
how do you explain exceptional responses in cancer patients
Do not trust the results! Always follow any references to check they are accurate and that AI has not invented or misinterpreted them, (or has been fooled by deliberate misinformation).
These authors go into great detail about mechanisms and possible treatments of the fibrosis and cancer evolution in both the pancreas and liver which have much in common. I will highlight things that I would investigate changing with diet and lifestyle changes if I had these problems. Only your licensed doctor can give you advice so discuss it with him.
Fibrosis typically follows prolonged
inflammation that has failed to resolve, gradually resulting in
the replacement of cellular components with a stiff fibrotic scar,
which substantially impairs normal tissue functions.
a persistent irritant cause
viral hepatitis, cholangitis (inflammation of the bile duct
system), drug toxicity, chronic alcohol abuse and
non-alcoholic steatohepatitis (NASH)
(Fatty Liver caused by
excess carbohydrates or lack of essential saturated fat
C15:0 from grass fed butter
) pancreatic cancer
acinar cells, which secrete digestive
enzymes, and islets of Langerhans, which release hormones such as
insulin, glucagon or somatostatin.
Once the tissue integrity has been disrupted, immune
cells or platelets start releasing pro-inflammatory
cytokines and chemokines
myofibroblasts are usually removed
via apoptotic cell death
as vitamin A-storing, stellate-shaped cells,
Quiescent PSCs also store retinoids as lipid
droplets in the cytoplasm
Importantly, PSCs have been shown to regulate inflammation,
angiogenesis and cancer cell biology via secretion of cytokines
and growth factors
by releasing NO, the same cells have a reducing
effect on HSC proliferation
T helper type 2 cells (Th2) promote fibrosis by
producing interleukins IL-4, IL-5, IL-13, whereas natural
killer cells (NK) secrete interferon gamma (IFN-γ ) that induces
HSC apoptosis and inhibits the development of fibrosis. showed
that a vasodilator Fasudil effectively prevented
thioacetamide-induced liver fibrosis in a mouse model – this
inhibitor of the Rho-associated protein kinase (ROCK) not only activated
NK cells, but also inhibited proliferation of HSCs and induced
their apoptosis . It was observed that in patients with advanced
stages of fibrosis the activity of NK cells was inhibited
Bile
acids and ethanol metabolites, common inducers of AP,
exert direct damage on PACs and trigger local organ autodigestion
Other factors that could play a role in PSC activation
include oxidative stress generated during ethanol
metabolism , hypoxia and hyperglycaemia
In PSCs, by targeting a G protein-coupled oestrogen receptor
(GPER) with its agonist tamoxifen (a chemotherapeutic
agent used to treat breast cancer), YAP was deactivated, the
process of differentiation towards myofibroblasts was inhibited and
the capacity for remodelling of ECM in pancreatic cancer was
reduced
all-trans retinoic acid (ATRA), an active
metabolite of vitamin A, was shown to downregulate actomyosin
contractility, decrease generation of high traction forces and
desensitise PSCs to the mechanical cues from the ECM
Accumulating
evidence suggests that mechanisms under- lying the development of
fibrosis in various organs are controlled by Ca2+
signals.
Redox-active species are predominantly
generated as by-products of oxidative phosphorylation,
Redox-active
species are also produced by immune cells, for example, neutrophils
and macrophages, during inflammatory processes in the
tissue
For example, supplementation with vitamins or small
molecule antioxidants relieved severe abdominal pain in patients
with chronic pancreatitis
supplementation with a potent antioxidant, coenzyme
Q10 (CoQ10 ), caused a drop in hepatic fibrosis score. CoQ10 has
already been used successfully in numerous randomised clinical
trials
There is a growing consensus that changes in the extracellular
pH may promote certain diseases, including those with fibrotic
basis. Solid tumours of the pancreas are characterised by a
microenvironment that is not only highly fibrotic but also acidic
cancer cells employ mechanisms to extrude excess acids, at
the same time lowering the extracellular pH of the
tumour microenvironment
fuelling a vicious circle of micro-
environmental acidification
lower interstitial pH, which
was attributed to impaired blood flow
Non-alcoholic fatty liver disease (NAFLD) is a condition
characterised by improper intrahepatocyte storage of excess lipids,
mostly triglycerides.
vitamin B12 deficiency
However, changes
in the patient’s lifestyle, for example, modification of dietary
habits and regular physical activity, can help to
relief NASH symptoms
the extensive deposition of ECM proteins may physically
compress capillaries and limit oxygen diffusion through the
severely distorted architecture of the pancreatic parenchyma, which
leads to hypoxic conditions in the developing tumours.
type 2 diabetes mellitus , a metabolic disorder
characterised by impaired functions of β-cells and insulin
resistance,
silibinin (the main compound of silymarin
extracted from milk thistle)
In attempts to restore quiescence in PSCs , ATRA
or vitamin D receptor (VDR) ligands have been tested. As mentioned
before, ATRA was demonstrated to restore the quiescent phenotype in
PSCs in vitro owing to the downregulation of actomyosin
contractility through a retinoic acid receptor β
(RAR-β)-dependent mechanism (Chronopoulos et al., 2016), whereas calcipotriol,
a VDR ligand, substantially reduced fibrosis in both pancreatitis
and human tumour stroma
He can measure your current body cancer markers e.g. Carcinoembryonic antigen (CEA) , CA-125, CA 19-9, hormones e.g. fasting insulin, IGF-1, organ functions, urine pH, serum vitamin D status, inflammation markers e.g CRP, blood markers e.g. full blood count, HbA1C, fasting glucose, imaging scans, biometric impedance estimates for body fat, lean muscle mass etc. By doing this he (and you) will know where you are currently with disease progression. Only with this baseline (and later repeat measurements) can you measure the effect of any treatments.
He can advise you if any of the following supplements are going to conflict with his treatments or your faulty pancreas bile and enzyme generation. Let him advise but you do not need his permission.
Knowing that blood glucose, fasting insulin, IGF-1, and a fatty liver are not helpful to pancreatic cancer growth signals, your doctor may well suggest dietary and exercise changes to improve these markers even though there aren't specific NICE guidelines for measuring fasting insulin and IGF-1 as biomarkers for pancreatic cancer.
If your doctor has read all the cancer research on melatonin and hormones he will also understand the need to reverse the Warburg effect and prevent metastatasis and will be adding high dose melatonin and possibly aspirin and possibly tamoxifen
Aware of inflammation, he will likely ban you from drinking alcohol, or eating carbohydrates such as wheat but have you doing regular walking exercise to reduce your blood glucose.
If your doctor feels that chemotherapy may be helpful, then he may stop all anti-oxidants and start you eating just bitter stuff with sulforaphane such as raw rocket, raw brussel sprouts, or even get you sprouting your own broccoli calabrese seeds. Despite not finding any official approval possible for fenbendazole, or ivermectin with it's 10 proven anti-cancer properties as you are not a dog or a horse, he will respect your patient wishes (as required to by NICE guidelines) and may prescribe these anyway to help you to import from other countries or compounders.
Your doctor knows the bad association of long term acidity inhibitors such as Omeprazole with cancer so will not be prescribing those, however maintaining urine pH in the region of 7.2 to 8.0 with a few grams of Sodium Bicarbonate may help ensure your blood never runs out of its bicarbonate buffer.
There is a supplement called mudplus which may reduce inflammation. This heat killed mycobacterium vaccae taken orally is pretty harmless as it is just a signal to your immune system.
From Mark Lintern's book "The Cancer Resolution".
Your doctor may be very constrained, short of time and inflexible. Relax! Sip your matcha green tea! It's your body. You have got this! It is a lot of research but everything you need *IS* obtainable online, and you can spend much time walking outside in the sun while you ponder. For starters, just order your urine pH meter, blood pressure meter, thermometer, pulse oximeter, blood glucose and ketones finger prick measurement device and electronic sensitive scales, rebounder, oxygen concentrator. You do not need your GP for these measurements.
Of course absolutely lovely to have the support and guidance of an integrative oncology doctor but these will cost several hundred pounds per consult and they are very much constrained by the laws of country they live in. Easier to do the research yourself so as not to trust advice from anyone.
There is private unpublished research into nuances of self constructed plans only available after discussion with me. Email me at chris.turner.cycom@gmail.com or call +44 7576 884014 for access.
Keep researching!. There is a lot of crazy research to increase the toxicity of chemotherapy against cancer cells but it is possible these toxins may destroy your immune function as well!. I would be very suspicious of attacks on mitochondria function or DNA repair as cancer cells were the result of these kinds of stress in the first place. I have been focusing on immune health and normal mitochondrial function using oxygen and avoiding anything with a toxic side effect on healthy cells.